Title: Top Hotels in Mississippi County | Expedia.ca [Vacation Rentals in Mississippi County](https://expedia.ca/Destinations-In-Mississippi-County.d553248635976432410.Vacation-Rental-Destinations)[Mississippi County Car Rentals](https://expedia.ca/Destinations-In-Mississippi-County.d553248635976432410.Car-Rental-Destinations)[Mississippi County Vacations](https://expedia.ca/Mississippi-County.d553248635976432410.Destination-Travel-Guides) ![MAY 17 2019, HERMANN MISSOURI USA - The Hermann Bridge was a cantilevered truss bridge over the Missouri River at Hermann, Missouri between Gasconade and Montgomery County](https://images.trvl-media.com/place/553248635976432410/2a0290c4-0f21-4601-a6ec-0bb9d391debf.jpg?impolicy=fcrop&w=1200&h=500&q=medium) ![](https://images.trvl-media.com/place/553248635976432410/2a0290c4-0f21-4601-a6ec-0bb9d391debf.jpg?impolicy=fcrop&w=1200&h=500&q=medium) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__calendar_shield.svg) ### Change your mind Book hotels with free cancellation - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Sign in to save 10% or more on thousands of hotels [Sign in](https://www.expedia.ca/login) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Top Cities in Mississippi County ![Cypress Trees on the Horizon. A sting of cypress trees of various sizes extend across the horizon as the sunken sun paints the multicolored sky. ](https://images.trvl-media.com/place/7182/2c4b1a06-d3aa-4171-b8b6-0e4eaaa0e80e.jpg?impolicy=fcrop&w=384&h=216&q=medium) #### Charleston [](https://expedia.ca/Charleston-Hotels.d7182.Travel-Guide-Hotels) ![The Mississippi River near Hannibal, Missouri, USA](https://images.trvl-media.com/place/6209928/2afb9a4b-494b-462a-af23-159cb6a96bb2.jpg?impolicy=fcrop&w=384&h=216&q=medium) #### East Prairie [](https://expedia.ca/East-Prairie-Hotels.d3000349349.Travel-Guide-Hotels) ## Check prices for these dates Tonight [Apr 3 - Apr 4](https://www.expedia.ca/Hotel-Search?regionId=553248635976432410&startDate=2026-04-03&endDate=2026-04-04&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Tomorrow [Apr 4 - Apr 5](https://www.expedia.ca/Hotel-Search?regionId=553248635976432410&startDate=2026-04-04&endDate=2026-04-05&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) This weekend [Apr 3 - Apr 5](https://www.expedia.ca/Hotel-Search?regionId=553248635976432410&startDate=2026-04-03&endDate=2026-04-05&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Next weekend [Apr 10 - Apr 12](https://www.expedia.ca/Hotel-Search?regionId=553248635976432410&startDate=2026-04-10&endDate=2026-04-12&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) ## Our top choices for Mississippi County hotels ![Laptop workspace, blackout drapes, free cribs/infant beds, free WiFi](https://images.trvl-media.com/lodging/1000000/990000/988800/988758/679acee6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/990000/988800/988758/bbf96e9f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/990000/988800/988758/a5038447.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily on-the-go breakfast](https://images.trvl-media.com/lodging/1000000/990000/988800/988758/1ca277a1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Super 8 by Wyndham Charleston/Sikeston East MO [](https://www.expedia.ca/Sikeston-Hotels-Super-8-By-Wyndham-Charleston-MO.h988758.Hotel-Information) Charleston 6.8/10 (628 reviews) "Affordable for a quick one night stay. Restaurant and gas station next to hotel." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Annette CA $88 CA $97 total includes taxes & fees Apr 12 - Apr 13 [](https://www.expedia.ca/Sikeston-Hotels-Super-8-By-Wyndham-Charleston-MO.h988758.Hotel-Information) ![Lobby sitting area](https://images.trvl-media.com/lodging/1000000/30000/20600/20594/a42cb957.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Standard Room, 1 King Bed, Non Smoking](https://images.trvl-media.com/lodging/1000000/30000/20600/20594/d0a59214.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/30000/20600/20594/08c2ace2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily buffet breakfast](https://images.trvl-media.com/lodging/1000000/30000/20600/20594/15abbdc3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### The Riverstone Hotel Charleston-Sikeston [](https://www.expedia.ca/Charleston-Hotels-The-Riverstone-Hotel.h20594.Hotel-Information) Charleston 6.8/10 (410 reviews) "Clean " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Chris CA $111 CA $123 total includes taxes & fees May 2 - May 3 [](https://www.expedia.ca/Charleston-Hotels-The-Riverstone-Hotel.h20594.Hotel-Information) ![Room, 1 King Bed, Non Smoking | View from room](https://images.trvl-media.com/lodging/5000000/4490000/4480300/4480270/183a17d9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Coffee service](https://images.trvl-media.com/lodging/5000000/4490000/4480300/4480270/8720ff7f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Room, 1 King Bed, Non Smoking | Bathroom](https://images.trvl-media.com/lodging/5000000/4490000/4480300/4480270/352edf3b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property entrance](https://images.trvl-media.com/lodging/5000000/4490000/4480300/4480270/ec6ce079.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Eagle Inn Charleston [](https://www.expedia.ca/Sikeston-Hotels-Eagle-Inn-Charleston.h4480270.Hotel-Information) Charleston 6.6/10 (105 reviews) "The hotel needs a renovation. For the price I didn’t expect much, but it feels neglected." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Britani CA $77 CA $85 total includes taxes & fees May 2 - May 3 [](https://www.expedia.ca/Sikeston-Hotels-Eagle-Inn-Charleston.h4480270.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/1000000/30000/21600/21513/f1c41457.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/30000/21600/21513/9d3e181d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Standard Room, 1 King Bed, Non Smoking](https://images.trvl-media.com/lodging/1000000/30000/21600/21513/e2b2c624.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Standard Room, 2 Double Beds, Non Smoking](https://images.trvl-media.com/lodging/1000000/30000/21600/21513/96f1c1e9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Quality Inn Cairo I-57 [](https://www.expedia.ca/Cairo-Hotels-Quality-Inn-Cairo-I-57.h21513.Hotel-Information) Cairo 6.6/10 (282 reviews) "Amenities, microwave, refrigerator,iron and iron board,Shower soap options " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Maurice CA $94 CA $104 total includes taxes & fees Apr 12 - Apr 13 [](https://www.expedia.ca/Cairo-Hotels-Quality-Inn-Cairo-I-57.h21513.Hotel-Information) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. [View all properties](https://expedia.ca/Hotel-Search?startDate=2026-04-18&endDate=2026-04-19®ionId=553248635976432410&adults=2&sort=RECOMMENDED&openPlayBack=true) ![](https://a.travel-assets.com/pricing-claim/sparkle_dark.svg) Save an average of 15% on thousands of hotels when you're signed in [Sign in ](https://expedia.ca/user/signin?ckoflag=0&uurl=e3id%3Dredr%26rurl%3D%2FDestinations-In-Mississippi-County.d553248635976432410.Hotel-Destinations)[ Sign up, it's free ](https://expedia.ca/signup?enable_registration=true&+=&uurl=e3id%3Dredr%26rurl%3D%2FDestinations-In-Mississippi-County.d553248635976432410.Hotel-Destinations) ## Top Mississippi County Hotel Reviews ![Fairfield Inn & Suites by Marriott Sikeston](https://images.trvl-media.com/lodging/112000000/111250000/111247500/111247451/f2cf9c54_y.jpg) ### Fairfield Inn & Suites by Marriott Sikeston 10/10 Excellent "Quick and friendly check where they offered us bottles of water. They added a lounge/bar that is very convenient. The outside lounge are is very nice as well. Room is clean with a comfortable bed and 2 different styles of pillows. Which is nice considering most hotels give you one kind of pillow and it is not great. " [](https://expedia.ca/Fairfield-By-Marriott-Inn-Suites-Sikeston.h111247451.Hotel-Information) ![3 bedroom house on Reelfoot Lake, perfect for families, fisherman and hunters](https://images.trvl-media.com/lodging/124000000/123260000/123259200/123259172/5c6ff00e_y.jpg) ### 3 bedroom house on Reelfoot Lake, perfect for families, fisherman and hunters 10/10 Excellent "My family and I stayed a week for Spring Break and had a great time. The lodge was spacious, beautiful, and extremely clean. The view of the lake and sunsets are amazing. The host was super friendly and very accommodating. Fun for all ages and we will go back!" [](https://expedia.ca/Hornbeak-Hotels-3-Bedroom-House-On-Reelfoot-Lake.h123259172.Hotel-Information) ![Drury Inn & Suites Sikeston, MO](https://images.trvl-media.com/lodging/1000000/30000/24300/24210/85184a8e_y.jpg) ### Drury Inn & Suites Sikeston, MO 10/10 Excellent "We decided we will stay here next year on our trip home from Texas." [](https://expedia.ca/Sikeston-Hotels-Drury-Inn-Suites-Sikeston.h24210.Hotel-Information) ![Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)](https://images.trvl-media.com/lodging/1000000/40000/34800/34745/47690ac7_y.jpg) ### Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67) 8/10 Good "Yes" [](https://expedia.ca/Sikeston-Hotels-Travel-Inn-Suites.h34745.Hotel-Information) ![Super 8 by Wyndham Charleston/Sikeston East MO](https://images.trvl-media.com/lodging/1000000/990000/988800/988758/679acee6_y.jpg) ### Super 8 by Wyndham Charleston/Sikeston East MO 6/10 Okay "Room was renovated and clean but the outside wasn’t updated. My children were scared to sleep there. Unfortunately no cable and when I asked to have it looked at nobody came. I just needed somewhere rest and it worked for that. But it wasn’t matching to the online photos. And a 100 dollar deposit ridiculous." [](https://expedia.ca/Sikeston-Hotels-Super-8-By-Wyndham-Charleston-MO.h988758.Hotel-Information) ![Sleep Inn at Discovery Park of America](https://images.trvl-media.com/lodging/39000000/38310000/38309600/38309567/2a51d3d0_y.jpg) ### Sleep Inn at Discovery Park of America 4/10 Poor "The staff was amazing.From the front desk clerk to the maids everyone was super nice and friendly...Even though they tried to make things right there were too many wrongs." [](https://expedia.ca/Union-City-Hotels-Sleep-Inn.h38309567.Hotel-Information) ![Hampton Inn Sikeston](https://images.trvl-media.com/lodging/26000000/25180000/25178200/25178175/77525d07_y.jpg) ### Hampton Inn Sikeston 8/10 Good "Yes, breakfast was fresh. Room temperature was comfortable. Overall stay was good. Would stay there again" [](https://expedia.ca/Sikeston-Hotels-Hampton-Inn-Sikeston.h25178175.Hotel-Information) ![Best Western Plus Sikeston I-55](https://images.trvl-media.com/lodging/9000000/8430000/8420600/8420572/29a4ab37_y.jpg) ### Best Western Plus Sikeston I-55 4/10 Poor "The bed and chair was hard. Will not go back" [](https://expedia.ca/Sikeston-Hotels-Best-Western-Plus-Sikeston.h8420572.Hotel-Information) ![Peaceful secluded cabin located near Horseshoe Lake ](https://images.trvl-media.com/lodging/110000000/109740000/109730100/109730068/1be40475_y.jpg) ### Peaceful secluded cabin located near Horseshoe Lake 10/10 Excellent "This was an amazing property. We our stay here with our doodles while hiking and exploring Shawnee Forest. Private, comfortable and unique! " [](https://expedia.ca/Peaceful-Secluded-Cabin-Located-Near-Horseshoe-Lake.h109730068.Hotel-Information) ## Explore a world of travel with Expedia - Explore a world of travel with Expedia ### Top cities in Mississippi County - [Charleston Hotels ](https://expedia.ca/Charleston-Hotels.d7182.Travel-Guide-Hotels) - [East Prairie Hotels ](https://expedia.ca/East-Prairie-Hotels.d3000349349.Travel-Guide-Hotels) - [Bertrand Hotels ](https://expedia.ca/Bertrand-Hotels.d3000349285.Travel-Guide-Hotels) - [Wyatt Hotels ](https://expedia.ca/Wyatt-Hotels.d553248634983534991.Travel-Guide-Hotels) - [Anniston Hotels ](https://expedia.ca/Anniston-Hotels.d553248634983588922.Travel-Guide-Hotels) ### Hotels near popular Attractions - [Hotels near Shawnee National Forest ](https://expedia.ca/Shawnee-National-Forest-Hotels.0-l553248635944113522-0.Travel-Guide-Filter-Hotels) - [Hotels near Mississippi River ](https://expedia.ca/Mississippi-River-Hotels.0-l6209928-0.Travel-Guide-Filter-Hotels) - [Hotels near Ohio River ](https://expedia.ca/Ohio-River-Hotels.0-l681940626945888256-0.Travel-Guide-Filter-Hotels) - [Hotels near Reelfoot Lake ](https://expedia.ca/Reelfoot-Lake-Hotels.0-l553248635976195913-0.Travel-Guide-Filter-Hotels) - [Hotels near Discovery Park of America ](https://expedia.ca/Discovery-Park-Of-America-Hotels.0-l553248621561866880-0.Travel-Guide-Filter-Hotels) - [Hotels near Reelfoot Lake State Park ](https://expedia.ca/Reelfoot-Lake-State-Park-Hotels.0-l553248621532655205-0.Travel-Guide-Filter-Hotels) - [Hotels near Ohio River Valley ](https://expedia.ca/Ohio-River-Valley-Hotels.0-l6233674-0.Travel-Guide-Filter-Hotels) - [Hotels near Sikeston Depot Museum ](https://expedia.ca/Sikeston-Depot-Museum-Hotels.0-l6305602-0.Travel-Guide-Filter-Hotels) - [Hotels near Central Park ](https://expedia.ca/Central-Park-Hotels.0-l6305608-0.Travel-Guide-Filter-Hotels) - [Hotels near Fort Defiance State Park ](https://expedia.ca/Fort-Defiance-State-Park-Hotels.0-l6091411-0.Travel-Guide-Filter-Hotels) ### More Accommodation Types in Mississippi County - [Vacation Homes in Mississippi County ](https://expedia.ca/Mississippi-County-Private-Vacation-Homes.d553248635976432410-aaPrivateVacationHomes.Travel-Guide-Accommodation) - [Lodges in Mississippi County ](https://expedia.ca/Mississippi-County-Lodges.d553248635976432410-aaLodges.Travel-Guide-Accommodation) - [Cabin Rentals in Mississippi County ](https://expedia.ca/Mississippi-County-Cabins.d553248635976432410-aaCabins.Travel-Guide-Accommodation) - [Motels in Mississippi County ](https://expedia.ca/Mississippi-County-Motels.d553248635976432410-aaMotels.Travel-Guide-Accommodation) - [Cottages in Mississippi County ](https://expedia.ca/Mississippi-County-Cottages.d553248635976432410-aaCottages.Travel-Guide-Accommodation) - [Apartments in Mississippi County ](https://expedia.ca/Mississippi-County-Apartments.d553248635976432410-aaApartments.Travel-Guide-Accommodation) - [RV Parks in Mississippi County ](https://expedia.ca/Mississippi-County-RV-Parks.d553248635976432410-aaRVParks.Travel-Guide-Accommodation) - [Condo Rentals in Mississippi County ](https://expedia.ca/Mississippi-County-Condos.d553248635976432410-aaCondos.Travel-Guide-Accommodation) ### Explore more hotels - [Super 8 by Wyndham Charleston/Sikeston East MO ](https://expedia.ca/Sikeston-Hotels-Super-8-By-Wyndham-Charleston-MO.h988758.Hotel-Information) - [The Riverstone Hotel Charleston-Sikeston ](https://expedia.ca/Charleston-Hotels-The-Riverstone-Hotel.h20594.Hotel-Information) - [Drury Inn & Suites Sikeston, MO ](https://expedia.ca/Sikeston-Hotels-Drury-Inn-Suites-Sikeston.h24210.Hotel-Information) - [Hampton Inn Sikeston ](https://expedia.ca/Sikeston-Hotels-Hampton-Inn-Sikeston.h25178175.Hotel-Information) - [Best Western Plus Sikeston I-55 ](https://expedia.ca/Sikeston-Hotels-Best-Western-Plus-Sikeston.h8420572.Hotel-Information) - [Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67) ](https://expedia.ca/Sikeston-Hotels-Travel-Inn-Suites.h34745.Hotel-Information) - [Sleep Inn at Discovery Park of America ](https://expedia.ca/Union-City-Hotels-Sleep-Inn.h38309567.Hotel-Information) - [Days Inn and Suites by Wyndham Sikeston ](https://expedia.ca/Sikeston-Hotels-Days-Inn-And-Suites-By-Wyndham-Sikeston.h22041.Hotel-Information) - [Peaceful secluded cabin located near Horseshoe Lake ](https://expedia.ca/Peaceful-Secluded-Cabin-Located-Near-Horseshoe-Lake.h109730068.Hotel-Information) - [Holiday Inn Express & Suites Union City by IHG ](https://expedia.ca/Union-City-Hotels-Holiday-Inn-Express-Suites-Union-City.h39579081.Hotel-Information) [See a list of all hotels in Mississippi County](https://expedia.ca/All-Mississippi-County-Hotels.d553248635976432410.Travel-Guide-City-All-Hotels) ### More ways to book - [Book Hotels in Mississippi County on Expedia.com ](https://www.expedia.com/Destinations-In-Mississippi-County.d553248635976432410.Hotel-Destinations) ### Expedia's Latest Trends Hotels - [Luxury Hotels in Oakville](https://expedia.ca/Oakville-Hotels-Luxury-Hotel.0-0-d553248634983528485-tLuxuryHotel.Travel-Guide-Filter-Hotels) - [Hotels in Wentzville](https://expedia.ca/Wentzville-Hotels.d7679.Travel-Guide-Hotels) - [Hotels near GEHA Field at Arrowhead Stadium](https://expedia.ca/GEHA-Field-At-Arrowhead-Stadium-Hotels.0-l6058069-0.Travel-Guide-Filter-Hotels) - 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[Marriott Hotels & Resorts Hotels in Oakville](https://expedia.ca/Oakville-Hotels-Marriott-Hotels-Resorts.0-0-d553248634983528485--bMarriottHotelsResorts.Travel-Guide-Filter-Hotels) - [Hotels near Women's and Children's Hospital](https://expedia.ca/Womens-And-Childrens-Hospital-Hotels.0-l553248635974865886-0.Travel-Guide-Filter-Hotels) - [Hotels near Powell Gardens](https://expedia.ca/Powell-Gardens-Hotels.0-l553248621532648297-0.Travel-Guide-Filter-Hotels) - [Southeast Springfield hotels](https://expedia.ca/Southeast-Springfield-Springfield-Hotels.0-n553248635976480658-0.Travel-Guide-Filter-Hotels) - [Power and Light District hotels](https://expedia.ca/Power-And-Light-District-Kansas-City-Hotels.0-n6162504-0.Travel-Guide-Filter-Hotels) - [Downtown Kansas City hotels](https://expedia.ca/Downtown-Kansas-City-Kansas-City-Hotels.0-n6058828-0.Travel-Guide-Filter-Hotels) Flights - [Cheap Flights from Adair County](https://expedia.ca/lp/flights/553248635976433873/flights-from-adair-county) Cars - [Car rental St. Louis Airport (STL)](https://expedia.ca/Car-Rentals-In-Lambert-St-Louis-Intl.d5002323.Car-Rental-Guide) - [Car rental Kansas City Airport (MCI)](https://expedia.ca/Car-Rentals-In-Kansas-City-Intl.d4801357.Car-Rental-Guide) Activities - [Things to do in Maryland Heights](https://expedia.ca/Things-To-Do-In-Maryland-Heights.d7347.Travel-Guide-Activities) Packages - [St. Louis Zoo](https://expedia.ca/St-Louis-Zoo-St-Louis.d502878.Vacation-Attraction) - [Missouri Botanical Gardens and Arboretum](https://expedia.ca/Missouri-Botanical-Gardens-And-Arboretum-St-Louis.d507258.Vacation-Attraction) - [Starlight Theatre](https://expedia.ca/Starlight-Theatre-South-Kansas-City.d6069373.Vacation-Attraction) - [St. Louis Art Museum](https://expedia.ca/St-Louis-Art-Museum-St-Louis.d502859.Vacation-Attraction) - [Kansas City Zoo](https://expedia.ca/Kansas-City-Zoo-South-Kansas-City.d501349.Vacation-Attraction) General - [Visit Dutchtown](https://expedia.ca/St-Louis-Dutchtown.dx896162373499555840) - [Visit Downtown St. Louis](https://expedia.ca/St-Louis-Downtown-St-Louis.dx800136) - [Visit Downtown Kansas City](https://expedia.ca/Kansas-City-Downtown-Kansas-City.dx6058828) - [Visit Parkville](https://expedia.ca/Parkville.dx9973) - [Visit River Market](https://expedia.ca/Kansas-City-River-Market.dx6192918) ![](https://a.travel-assets.com/mad-service/footer/bnaBanners/BEX_Footer.jpg) ## Go further with the Expedia app Save on select hotels and earn double points when you book on the app. Our app deals help you to save on trips so you can travel more and manage it all on the go. 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